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To compute skews, the input sequence is scanned with a sliding window, and the requested parameter is calculate
for each window. The data is shown in a graph.
G+C %
The porcentaje of G+C is computed
GC-skew
For each window, (G-C)/(G+C) is computed, where G and C are the number of ocurrences for each nucleotide
AT-skew
For each window, (A-T)/(A+T) is computed, where A and T are the number of ocurrences for each nucleotide.
KETO-skew
For each window, (G+C-A-T)/(G+C+A+T) is computed, where A, C, G and T are the number of ocurrences for each nucleotide.
Oligo-skew
For each window, frecuencies for all nucleotides with selected length is computed.
Those frecuencies are compared to frecuencies obtained from the complete sequence.
When comparing both frecuencies, Pearson distance is computed, as described
here.
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